Zvinoenderana nechidzidzo chitsva, cannabinoids inogona kuve inoshanda kupfuura afatinib yeHER2-positive cancers.

Ongororo ichangoburwa yakaburitswa nechikwata chaKiattawee Chowongkomon paKasetsart University kuThailand. Chidzidzo ichi chinonzi "Cannabinoids sePromising Inhibitors yeHER2-Tyrosine Kinase: Nzira Itsva yeTarget HER2-Positive Ovarian Cancer".Chidzidzo ichi chakaratidza kuti cannabinoids, kunyanya CBD uye CBG, inogona kuve yakanaka sarudzo seimwe nzira kana yekuwedzera marapirwo eHER2-positive cancers. Aya cannabinoids anogona kubatsira kuderedza kusagadzikana kwezvinodhaka uye zvakaipa mhedzisiro.

Chidzidzo ichi chakaongorora kushanda kwe cannabidiol (CBD), cannabigerol (CBG), uye cannabinol (CBN) paHER2-positive ovarian cancer vachishandisa nzira inonzi "kinase inhibition assay, Nicoya OpenSPR," uye yakaona kuti CBD neCBG inosunga zvakasimba uye ichivharira chiito cheHER2-TK.

HER2-positive cancers (semuenzaniso, kenza yemazamu, kenza yeovarian) ine hukasha uye inowanzopararira, nekuda kweHER2 receptor iri kushanda zvisina kufanira. Zvirwere zvekenza izvi zvinoumba inenge 15% -20% yekenza yemazamu.8 Mishonga yakajairika inoshandisa monoclonal antibodies (eg, trastuzumab) uye tyrosine kinase inhibitors (TKIs, eg, lapatinib), asi marapirwo aya kazhinji haashande zvakanaka nekuda kwekudzivisa. Around 50% yevarwere vanogadzira HER2 mutations kana bypass signing activation mushure mekurapwa, izvo zvinotungamira mukufambira mberi kwechirwere.

Mumakore achangopfuura, zvigadzirwa zvechisikigo zvakawana kutariswa kwekugona kwavo kunanga nyaya dzakawanda uye nekuchengetedzeka. Zvimwe zvigadzirwa zvechisikigo, senge cannabinoids (CBD, CBG), zvakaratidza anti-kuzvimba uye pro-apoptotic kugona muzvidzidzo zvidiki, asi isu hatinyatso nzwisisa maitiro avanoita pane HER2 zvinangwa. Ichi chidzidzo ndechekutanga kuongorora zvakarongeka zvivakwa zve cannabinoids kuHER2-TK uye kuongorora kugona kwavo sezvivharidzo zvitsva.

SPR tekinoroji inoita basa rakakosha munzvimbo dzakawanda, kubva pakudzidza kuti mamorekuru anopindirana sei kusvika pakushandisa data kuita sarudzo.

Chikwata chakashandisa chishandiso chinonzi Nicoya OpenSPR kudzidza kuti CBD, CBG, CBN, uye afatinib (yakajairika TKI) inosunga sei kuHER2-TK. Mhedzisiro yacho yaishamisa: CBD inosunga zvakasimba kuHER2-TK, ine dissociation yenguva dzose ye6.16 μM chete, iyo yakakwirira kudarika iyo yeafatinib. CBG inoitawo zvakanaka, iine dissociation yenguva dzose ye17.07 μM, uye ine mwero inosunga hukama. Izvi zvinoratidza kuti CBD uye CBG inogona kubata zvakasimba HER2-TK, iyo inogona kubatsira kumisa cancer maseru kukura.

CBD (Cannabidiol, Cannabidiol) Molecular Weight: 314.46 g/mol
CBG (Cannabigerol, Cannabis Terpene Glycol) Molecular Weight: 316.47 g/mol
CBN (Cannabinol, Cannabinol) Molecular Weight: 310.43 g/mol
Afatinib (Afatinib, control molecule) Molecular Weight: 485.93 g/mol

Kubva pamaonero ekuti vanogona sei kuvharisa mamwe mapuroteni, bvunzo dzakaratidza kuti CBG neCBD zvinogona kumisa basa reHER2-TK. Yakasanganiswa nezvidzidzo zvemamolecular docking zvakaratidza kusangana kwe cannabinoids nezvikamu zvakakosha zveHER2 - TK (Leu796, Thr862, Asp863), izvi mhedzisiro inoratidza kuti cannabinoids inogona sei kuita anticancer mhedzisiro. Vanoita izvi nekudyidzana neHER2 - TK, inhibiting yayo kinase chiitiko, uye ichivharira nzira yekusaina.

Muchidimbu, mhinduro idzi dzinoratidza kuti cannabinoids, kunyanya CBD uye CBG, ine zvakawanda zvinogoneka mukurapa HER2-positive cancers. Inogona kushandiswa sedzimwe nzira kana kuwedzera kune yakajairika marapirwo kubatsira varwere kuderedza kuramba kurapwa uku uye kuderedza mhedzisiro. Zvisinei, tsvakurudzo ichiri mumatanho ekutanga. Zvimwe zvidzidzo zvinodiwa mune ramangwana. Zvidzidzo izvi zvinofanirwa kujekesa nzira chaidzo dzinoshanda necannabinoids. Vanofanirawo kuongorora maitiro ekugadzirisa iyo musanganiswa regimen. Mukuwedzera, miedzo yekiriniki inofanira kuitwa kuti isimbise kuchengeteka kwavo uye kushanda.

Chidzidzo ichi chinogadzira mazano matsva ekurapa HER2-positive cancers neSPR tekinoroji uye mamwe maturusi. Mune ramangwana, isu tinotarisira kushandisa cannabinoids mukurapa kwekiriniki, izvo zvinogona kupa varwere vekenza tariro itsva uye hupenyu hutsva.